Development of a Creatinine Sensor Based on a Molecularly Imprinted Polymer-Modified Sol-Gel Film on Graphite Electrode

✍ Scribed by Amit Kumar Patel; Piyush Sindhu Sharma; Bhim Bali Prasad

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 682 KB
• Volume: 20
• Category: Article
• ISSN: 1040-0397
• DOI: 10.1002/elan.200804294

✦ Synopsis

Abstract

An electrochemical creatinine sensor based on a molecularly imprinted polymer (MIP)‐modified sol‐gel film on graphite electrode was developed. The surface coating of MIP over sol‐gel was advantageous to obtain a porous film with outwardly exposed MIP cavities for unhindered selective rebinding of creatinine from aqueous and biological samples. A fast differential pulse, cathodic stripping voltammetric response of creatinine can be obtained after being preanodized the sensor in neutral medium containing appropriate amount of creatinine at +1.8 V versus SCE for 120 s. A linear response over creatinine concentration in the range of 1.23 to 100 μg mL^−1^ was exhibited with a detection limit of 0.37 μg mL^−1^ (S/N=3).