The biologic response to surgical implants is of importance in understanding the host interactions relating to long-term patency of implants. The methodology currently available for the assessment of host-biomaterial interactions is subjective and is limited to identification of inflammatory respons
Development of 203Pb as a new label for monoclonal antibodies
โ Scribed by S.C. Srivastava; G.E. Meinken; R.C. Mease; L.F. Mausner; Z. Steplewski
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- French
- Weight
- 174 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
โฆ Synopsis
n 3 Nitrate 2 hre 5.21 * 0.065 9.87 * 0.82 37.4 * 8.83 9.36 0.47 1.47 * 0.06 78 24 hre 7.7 2 1.5 6.0 _+ 0.5 27.6 _+ 1.0 12.1 _+ 0.7 0.4 _+ 0.15 58 48 hre 1.8 * 0.32 3.34 * 0.73 15.2 * 1.69 13.3 * 1.05 0.44 * 0.21 61 -11 3-DTPAC 3 hr 1.09 * 0.04 1.24 * 0.11 5.46 * 0.26 1.00 * 0.06 -71 2 hrd 7.9 * 0.4 10.2 0.6 36.9 * 3.0 7.1 * 0.8 -3-17-1A-DTPA 24 hrd 5.9 * 0.5 6.3 * 1.0 20.7 * 2.6 9.5
* 1.1 54 -48 hrd 2.00 _+ 0.40 4.24 _+ 1.16 12.10 _+ 1.41 12.00 2 0.94 47 24 hre 3.57 * 0.11 5.32 * 0.15 15.3 * 3.3 13.3 * 0.6 12.8 * 1.2 61 96 hre 0.93 * 0.12 2.69 0.42 6.32 * 1.50 8.10 0.32 -35 2 hr 32.4 * 1.1 13.9 * 1.5 7.1 * 0.8 2.7 0.3 -115 1-17-1A-DTPA 24 hr 12.9 * 1.9 17.1 * 4.4 12.2 2.0 3.6 * 0.3 -96 24 hre 10.9 * 4.5 9.4 * 0.6 6.9 * 1.5 4.3 1.1 7.8 * 2.4 104 48 hre 7.27 _+ 2.41 9.02 2 0.91 8.03 _+ 0.23 4.53 _+ 0.86 7.49 _+ 0.06 102 96 hre 1.81 2 1.0 8.46 _+ 1.17 7.23 2 1.01 4.08 _+ 0.90 4.54 _+ 1.03 76 mal BNL mice, n=4, except as noted. cent retention 7 All data normalized to 25 g body weight.
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Background. The development of new bifunctional chelating agents for the labeling of monoclonal antibodies with radiometals is a desirable goal in the area of radioimmunodetection and radioimmunotherapy of cancer. The authors have developed a new N,S-ligand, N-(S-acetylmercaptoacetyl) (p-NCS)phenyla