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Development and validation of a simple and sensitive method for quantification of levodopa and carbidopa in rat and monkey plasma using derivatization and UPLC–MS/MS

✍ Scribed by Junnotula, Venkatraman; Licea-Perez, Hermes


Book ID
120174386
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
473 KB
Volume
926
Category
Article
ISSN
1873-376X

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A sensitive and fast high-performance liquid chromatography-electrospray ionization-MS/MS method for the simultaneous quantitation of levodopa and carbidopa in human plasma was developed and validated. A simple protein precipitation step with perchloric acid was used for the cleanup of plasma, and m