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Development and validation of a sensitive and robust LC–MS/MS with electrospray ionization method for simultaneous quantitation of quetiapine and its active metabolite norquetiapine in human plasma

✍ Scribed by Xiong, Xin; Yang, Li; Duan, Jingli

Book ID
120655668
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
549 KB
Volume
423
Category
Article
ISSN
0009-8981

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Development and validation of a sensitive LC-MS/MS method with electrospray ionization for quantitation of pramipexole in human plasma: application to a clinical pharmacokinetic study
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## Abstract A highly sensitive and specific LC‐MS/MS method has been developed and validated for the estimation of pramipexole (PPX) with 500 µL human plasma using memantine as an internal standard (IS). The API‐4000 was operated under multiple‐reaction monitoring mode (MRM) using the electrospray