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Development and validation of a rapid method for the determination and confirmation of 10 nitroimidazoles in animal plasma using liquid chromatography tandem mass spectrometry

✍ Scribed by Mark Cronly; Patrice Behan; Barry Foley; Edward Malone; Liam Regan

Book ID: 108160997
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 554 KB
Volume: 877
Category: Article
ISSN: 1873-376X
DOI: 10.1016/j.jchromb.2009.03.030

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## Abstract A rapid and sensitive liquid chromatography–tandem mass spectrometry (LC‐MS/MS) method has been developed and validated for the estimation of nicorandil in human plasma. Nicorandil was extracted from human plasma using solid‐phase extraction technique. Imipramine was used as the interna