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Development and validation of a LC/MS/MS method for 6-keto PGF1α, a metabolite of prostacyclin (PGI2)

✍ Scribed by Derek L. Chappell; Xiaoyao Xiao; Waldemar Radziszewski; Omar F. Laterza

Book ID
113743093
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
317 KB
Volume
56
Category
Article
ISSN
0731-7085

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Setting up a 2D-LC/MS/MS method for the rapid quantitation of the prostanoid metabolites 6-oxo-PGF1α and TXB2 as markers for hemostasis assessment
✍ Bruno Casetta; Gennaro Vecchione; Michela Tomaiuolo; Maurizio Margaglione; Elvir 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 449 KB 👁 1 views

## Abstract 6‐oxo‐PGF~1α~ and TXB~2~ are the metabolites of the prostanglandin PGI~2~ and of the thromboxane TXA~2~, respectively. PGI~2~ and TXA~2~ are arachidonic acid‐derived compounds which regulate the blood hemostasis. Their quick metabolism leads to the 6‐oxo‐PGF~1α~ and TXB~2~ metabolites i