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Development and validation of a capillary electrophoresis method for the enantiomeric purity determination of SLV307, a basic potential antipsychotic compound

✍ Scribed by Pim G. Muijselaar; Norbert G. F. M. Lammers; Thijs K. Gerding

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
99 KB
Volume
25
Category
Article
ISSN
0173-0835

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✦ Synopsis

Abstract

A capillary electrophoresis method for the enantiomeric purity determination of SLV307, a basic potential antipsychotic compound, has been developed and validated. It is shown that the presence of the eutomer in the sample solution may have a significant effect on the peak shape of the distomer, due to electrodispersion. The method is shown to give good performance with respect to the validation parameters specificity, linearity, accuracy, precision, determination limits, stability of solutions, and robustness of extraction.

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