Development and potential role of type-2 sodium-glucose transporter inhibitors for management of type 2 diabetes
β Scribed by Timothy Colin Hardman; Simon William Dubrey
- Book ID
- 107697271
- Publisher
- Springer-Verlag
- Year
- 2011
- Tongue
- English
- Weight
- 781 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1869-6953
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π SIMILAR VOLUMES
## Abstract The human kidney has a key role in the regulation of blood glucose predominantly by reabsorption of glucose from the glomerular filtrate via sodium glucose coβtransporter 2 (SGLTβ2) channels. These are expressed in the proximal renal tubules and are blocked by SGLTβ2 inhibitors, which a
## Abstract Current strategies for the treatment of type 2 diabetes target deficient insulin secretion and insulin resistance, but have not been shown to correct the progressive Ξ²βcell dysfunction characteristic of the disease. Traditionally, type 2 diabetes is treated in a stepwise manner with med