## Abstract A threeโdimensional pharmacophore model was developed from a series of inhibitors of Aurora A kinase to discover new potent antiโcancer agents using the HypoGen module in the Catalyst software. The pharmacophore model was developed based on the structure of 20 currently available inhibi
Development and Biological Evaluation of a Novel Aurora A Kinase Inhibitor
โ Scribed by Teresa Sardon; Thomas Cottin; Jing Xu; Athanassios Giannis; Isabelle Vernos
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 948 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1439-4227
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๐ SIMILAR VOLUMES
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
## Abstract Sodium ringโ[^14^C]โ4โ[[9โchloroโ7โ(2,6โdifluorophenyl)โ__5H__โpyrimido[5,4โ__d__][2]benzazepinโ2โyl]amino]โbenzoate (1A, MLN8054), an Aurora A kinase inhibitor, was synthesized from [^14^C]โcyanamide in two steps in an overall radiochemical yield of 7%. The intermediate, [^14^C]โ4โguan