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Developing Peptide Inhibitors to Thrombin Activation of Platelets from Bradykinin Analogs

โœ Scribed by Ahmed A.K. Hasan; Mark Warnock; Sujata Srikanth; Alvin H. Schmaier


Book ID
117257160
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
238 KB
Volume
104
Category
Article
ISSN
0049-3848

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A solid phase chemistry approach utilizing Mitsunobu chemistry, amine functionalization, and parallel purification was used to produce a diverse library of benzothiophene analogs. These analogs were used to advance the SAR of this class of molecules and give new directions for future studies.