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Deuteration of catecholamines, catecholamine metabolites and tryptophan metabolites

✍ Scribed by Frits A. J. Muskiet; Hans J. Jeuring; Cornelis G. Thomasson; Jan Van Der Meulen; Bert G. Wolthers

Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
282 KB
Volume
14
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The preparation of some deuterium labelled catecholamines, catecholamine metabolites and tryptophan metabolites is described. Simple exchange reactions in DC1/D~2~0 solution or reductions with Li Al D~4~ were used. The deuterium labelled compounds prepared are suitable for use as internal standards for quantitative mass‐fragmentographic analysis of their unlabelled analogs in biological material. Mass spectra of trimethylsilyl and trimethylsilyl‐N‐trifluoroacetyl derivatives of 2,5,6‐trideutero vanillactic acid, 1,1‐dideutero‐1‐hydroxy‐2 (2,5,6‐trideutero catechol)‐ethane, 2,5,6‐trideutero epinephrine, 2,5,6‐trideutero normetanephrine and hexadeutero indole‐3‐acetic acid are given together with those of their natural occurring analogs.

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