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Deuteration and solvent composition effects in the helix–coil transition of poly-γ-beiizyl-L-glutamate

✍ Scribed by F. E. Karasz; J. M. O'Reilly

Publisher
Wiley (John Wiley & Sons)
Year
1966
Tongue
English
Weight
479 KB
Volume
4
Category
Article
ISSN
0006-3525

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✦ Synopsis

The effects of deuteration and of changes in solvent composition on the thermodynamics of the helix-coil transition have been studied by calorimetric and optical measurements in the poly-7-benzyl-Lglutamatedichloroacetic acid-l,%dichloroethane system. For a given solvent composition, deuteration of the polypeptide and of the acid lowers the transition temperature T,, while an increase in the volume fraction of acid in the solvent raises T,. A rise in T , is accompanied by a decrease in both the van't Hoff and the calorimetric heats of transition, but at different rates. The result is a temperature dependency in the Zimm-Bragg cooperation parameter U. Possible causes of this result and its implications are discmsed.

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