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Determination of two metoprolol metabolises in human urine by high-performance liquid chromatography

✍ Scribed by J. Godbillon; M. Duval

Publisher
Elsevier Science
Year
1984
Weight
279 KB
Volume
309
Category
Article
ISSN
0378-4347

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## Abstract A simple, specific and sensitive HPLC method has been developed for the determination of metoprolol in human plasma and urine. Separation of metoprolol and atenolol (internal standard) was achieved on an Ace C~18~ column (5 μm, 250 mmΓ—4.6 mm id) using fluorescence detection with Ξ»~ex~=2