Determination of the N-methyl stereochemistry in tropane and granatane derivatives in solution: a computational and NMR spectroscopic study
✍ Scribed by Ryszard Lazny; Artur Ratkiewicz; Aneta Nodzewska; Anna Wynimko; Leszek Siergiejczyk
- Book ID
- 116909511
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- French
- Weight
- 276 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0040-4020
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## Abstract Two different __N__‐configurations and two different eight‐membered ring conformations were found in the diastereomeric crystalline (1__R__,3__S__)/(1__S__,3__R__)‐ and (1__S__,3__R__)/(1__S__,3__S__)‐3‐methylnefopam hydrochloride salts. ^1^H and ^13^C NMR spectroscopy showed that both
## Abstract The analysis of ^15^N chemical shift data from over a hundred anilines, __N__‐methyl anilines, __N__,__N__‐dimethyl anilines and phenylhydrazines with substituents in the phenyl ring leads to an empirical equation, δ~cal~ = δon + Δ__o__ + Δ__m__ + Δ__p__, for calculating ^15^N NMR chemi