Determination of the Mitins, Sulcofuron and Flucofuron, Using Liquid Chromatography Combined with Negative-ion Electrospray Ionization Mass Spectrometry†

✍ Scribed by P. M. Hancock; S. J. G. White; D. A. Catlow; P. J. Baugh; G. A. Bonwick; D. H. Davies

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 169 KB
• Volume: 11
• Category: Article
• ISSN: 0951-4198
• DOI: 10.1002/(sici)1097-0231(19970131)11:2<195::aid-rcm745>3.0.co;2-g

✦ Synopsis

Flucofuron and sulcofuron, both examples of mitins, have been employed as the active ingredients in mothproofing formulations for the protection of textile fabrics by the dyeing industry. Monitoring of their presence in components of the river ecosystem is a regulatory requirement so that sensitive detection techniques are required to obtain valid data concerning the levels of target pollutants present. Several methods have previously been reported for their determination but most of these methods are either inefficient or meet with some difficulty when dealing with trace residues in environmental matrices. This study has focused on the development of a highly sensitive and specific method of detection for these analytes, employing liquid chromatography combined with negative-ion electrospray ionization mass spectrometry operated in multiple-reaction monitoring (MRM) mode. Linearity was observed for both analytes (2.5-2500pg) with correlation coefficients of 0.999 obtained routinely. The absolute instrumental limits of detection in MRM mode, defined as a signal-to-noise ratio of 3:1, were calculated to be 2.5pg and 10pg for flucofuron and sulcofuron, respectively.