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Determination of the enantiomeric composition of mexiletine and its four hydroxylated metabolites in urine by enantioselective capillary gas chromatography

✍ Scribed by Beate Knoche; Bärbel Gehrcke; Wilfried A. König; Irving W. Wainer

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 495 KB
Volume: 8
Category: Article
ISSN: 0899-0042
DOI: 10.1002/(sici)1520-636x(1996)8:1<30::aid-chir7>3.0.co;2-k

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✦ Synopsis

The enantiomers of mexiletine and four of its hydroxylated metabolites were directly separated by capillary gas chromatography using a heptakis(6-0-tert-butyldimethylsilyl-2,3-di-O-methyl)-p-cyclodextrin column. The method was applied to the analysis of urine samples from cancer patients who were treated with racemic mexiletine as part of a study of the use of mexiletine in the relief of neuropathic pain. Samples analyzed before and after deconjugation of the urine with p-glucuronidase/arylsulfatase showed a high stereoselectivity in the formation and conjugation of these compounds.

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