Determination of the degree of crystallinity in solid-solid equilibria

✍ Scribed by D. J. Allen; K. C. Kwan

• Book ID: 102913465
• Publisher: John Wiley and Sons
• Year: 1969
• Tongue: English
• Weight: 563 KB
• Volume: 58
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600581004

✦ Synopsis

A method based on dissolution rates was developed for estimating the ratio of crystalline drug to that dispersed at the molecular level within a carrier. In two diverse systems, it was shown that under appropriately chosen conditions, the dissolution rate of the drug was linearly related to its degree of crystallinity.

Keyphrases I J Crystallinity-solid-solid equilibria 0 Polymorphic forms-indomethacin, sulfathiazole 0 Indomethacin-PEG systems-dissolution rates Sulfathiazole-urea systems-dissolution rates 0 Dissolution rates-surface area relationship