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Determination of the Absolute Configuration of Synerazol.

✍ Scribed by Yasuhiro Igarashi; Yukihiro Yabuta; Tamotsu Furumai


Publisher
John Wiley and Sons
Year
2005
Weight
11 KB
Volume
36
Category
Article
ISSN
0931-7597

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## Resolution of pentahelicene (4) was recently described['! We have now succeeded in the first allocation of absolute configuration to a helicene, namely to (+ )-( 4). The fundamental investigations of Mislow et al. ['], later confirmed by X-ray structure analysis[31, have shown that

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In the past, Chirality has published a few review articles focused on some methods useful for determination of absolute configuration. However, in view of the rapid progress in the field, and in particular, of the recent advancement of computational methods, we found it appropriate to summarize the