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Determination of the Absolute Configuration of Restricted 1,1'-Binaphthyls by Asymmetric Meerwein-Ponndorf-Verley Reduction 1

✍ Scribed by Mislow, Kurt; McGinn, Francis A.


Book ID
126136112
Publisher
American Chemical Society
Year
1958
Tongue
English
Weight
411 KB
Volume
80
Category
Article
ISSN
0002-7863

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Asymmetric reduction and Meerwein-Ponndo
✍ Hu Xianming; Richard M. Kellogg 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 736 KB

## Abstract In THF solution, NaBH~4~ in the presence of (__S__)‐(‐)‐1‐(2‐chlorophenyl)‐2,2‐dimethylpropane‐1,3‐diol together with 2‐chlorobenzoic acid reduced propiophenone to 1‐ phenylpropan‐1‐ol in up to 40% enantiomeric excess (__ee__). Only 21% __ee__ was obtained without an added acid. (__R__)