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Determination of the absolute configuration of a key tricyclic component of a novel vasopressin receptor antagonist by use of vibrational circular dichroism

✍ Scribed by Alexey B. Dyatkin; Teresa B. Freedman; Xiaolin Cao; Rina K. Dukor; Bruce E. Maryanoff; Cynthia A. Maryanoff; Jay M. Matthews; Rekha D. Shah; Laurence A. Nafie

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
122 KB
Volume
14
Category
Article
ISSN
0899-0042

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## Abstract Vibrational circular dichroism (VCD) measurements and density functional theory (DFT) calculations were used to obtain the first definitive assignment of the absolute configuration for the polyphenolic binaphpthyl dialdehyde gossypol and a determination of the solution conformation in C