𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Determination of thalidomide in human plasma: methodological design for clinical trials

✍ Scribed by A.W. Lyon; G. Duran; V.A. Raisys

Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
114 KB
Volume
27
Category
Article
ISSN
0009-9120

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✦ Synopsis

was 4.1% (n=9) for the commercial control. The mean concentrations found for CLOZ in the controls were 1550 nmol/L and 990 nmol/L respectively, representing 103% and 99% of the weighed-in amounts. Relative recoveries from patients' serum samples supplemented with CLOZ (n=6) averaged 100.5% while analytical recovery averaged 96.4% for the 300 nmol/L standard and 93.2% for the 3000 nmol/L standard. Interferences from endogenous serum constituents and drugs that could be routinely coprescribed with clozapine were not found. The CLOZ metabolite, clozapine-n-oxide, which coresolved with CLOZ will on average, elevate CLOZ levels by a clinically irrelevant factor of 0.075. Simplicity, accuracy, precision, sensitivity and speed of analysis lend this assay to use in the clinical laboratory setting.

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