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Determination of tetracycline hydrochloride in presence of anhydrotetracycline by differential pulse polarography

✍ Scribed by S. Sabharwal; Kamal Kishore; P. N. Moorthy

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
234 KB
Volume
77
Category
Article
ISSN
0022-3549

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✦ Synopsis

A differential pulse polarographic method is described for the determination of the antibiotic tetracycline HCI in the presence of its degradation product anhydrotetracycline. The method utilizes the large difference in their differential pulse polarograms at a peak potential of -1.39 V in 0.1 M phosphate buffer as the base electrolyte (pH 6.8). The assay was evaluated using synthetic mixtures and applied to the analysis of commercial tetracycline HCI samples. The results obtained with this method are in close agreement with those from the spectrophotometric absorbance ratio method.

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