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Determination of flucytosine in tablets by differential pulse polarography

✍ Scribed by F. W. Teare; R. N. Yadav; M. Spino

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
256 KB
Volume
67
Category
Article
ISSN
0022-3549

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✦ Synopsis

A differential pulse polarographic assay was developed for determining flucytosine in tablets. The drug is extracted from the sample with water and hydrochloric acid and, after the pH is adjusted, an aliquot is added to the cell and the solution is polarographed at the dropping mercury electrode versus the saturated calomel electrode with 0.066 M SΓΈrensen phosphate buffer (pH 5.6) as the supporting electrolyte. The polarographic peak height enables precise quantitative determination. The Ep value for flucytosine is--1.54 v versus the saturated calomel electrode. The mean recovery of the drug is 101.5% +/- 1.9 (SD). The method is simple, rapid, and precise.

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