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Determination of tenatoprazole enantiomers and their enantioselective pharmacokinetics in rats

✍ Scribed by Jin Guan; Jing Yang; Jingjing Li; Xiaohong Li; Famei Li


Book ID
102072612
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
216 KB
Volume
21
Category
Article
ISSN
0899-0042

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Acebutolol (AC) is a chiral b-blocker which is extensively metabolized to an active, chiral metabolite, diacetolol (DC). Similar to some other b-adrenoceptors, AC exhibits multiple peaks in plasma concentrationΒ±time curves after oral doses to humans. We examined the suitability of the rat as an anim