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Determination of Sulfamethoxazole and Trimethoprim and Their Metabolites in Hospital Effluent

✍ Scribed by Carla G. B. Brenner; Carlos A. Mallmann; Daniel R. Arsand; Francieli M. Mayer; Ayrton F. Martins


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
430 KB
Volume
39
Category
Article
ISSN
1863-0650

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## Abstract A reversed‐phase HPLC assay method was developed to determine levels of the drugs trimethoprim, sulfamethoxazole and the N~4~‐acetyl metabolite of the latter in human blood plasma and urine. The organic substances are extracted with ethyl acetate by a single extraction at pH 6.8. The me