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Determination of streptomycin in pharmaceutical preparations by gas chromatography

✍ Scribed by Arrowood, Susan ;Hoyt, Arthur M. ;Woods, Mark W.

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
316 KB
Volume
14
Category
Article
ISSN
0935-6304

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✦ Synopsis

Abstract

The antibiotic streptomycin can be reliably quantitated in injectable pharmaceuticals by GC. The manipulations are not difficult, and total analysis time for duplicate samples is less than twenty minutes.

Reaction of the drug with aqueous sodium hydroxide solution generates maltol, which is extracted into chloroform prior to silylation. The silyl ether of maltol is then assayed, using naphthalene as internal standard. Duplicate analyses of twenty pharmaceutical samples showed a relative standard deviation of Β±1.3%.

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