✍ Scribed by Farmer, E. C.; Berstein, I. A.
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The possibilities of tritium labelling of tofizopam (**1**) at high specific activity were investigated. Two methods, one by isotopic exchange, and one by catalysed halogen‐tritium replacement were developed. The latter was found to be more rational, and **1** specifically labelled with
## Abstract Tritium labelled amitriptyline (__1__) of high specific activity was prepared. The tritium was incorporated by catalysed isotope exchange into the precursor dibenzosuberone, which had been previously converted into a cyclic ketal, in order to protect the oxo‐group against reduction. It
Trifluoperazine labelled with tritium at a specific activity of 3.15 TBq/mmol was prepared by methylation of N-desmethyltrifluoperazine with no-carrier added [3H]methyl iodide. An improved method for preparation of the precursor is also deacribed.