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Determination of selective serotonin reuptake inhibitors in plasma and urine by micellar liquid chromatography coupled to fluorescence detection

โœ Scribed by Agrawal, Nitasha; Esteve-Romero, Josep; Bose, Devasish; Dubey, Neeti Prakesh; Peris-Vicente, Juan; Carda-Broch, Samuel


Book ID
125798438
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
842 KB
Volume
965
Category
Article
ISSN
1873-376X

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## Abstract A simple, specific and sensitive HPLC method has been developed for the determination of metoprolol in human plasma and urine. Separation of metoprolol and atenolol (internal standard) was achieved on an Ace C~18~ column (5โ€‰ฮผm, 250โ€‰mmร—4.6โ€‰mm id) using fluorescence detection with ฮป~ex~=2