Determination of ring conformation in piperidine derivatives by IR spectroscopy
β Scribed by T. F. Vlasova; Yu. N. Sheinker
- Publisher
- Springer US
- Year
- 1971
- Tongue
- English
- Weight
- 256 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0021-9037
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π SIMILAR VOLUMES
Three different conformations of proline rings in a protein in solution, Up, Down and Twist, have been distinguished, and stereospecific assignments of the pyrrolidine beta-, gamma- and delta-hydrogens have been made on the basis of 1H-1H vicinal coupling constant patterns and intraresidue NOEs. For
## Abstract Protein misfolding and aggregation are involved in a number of the soβcalled βconformationalβ diseases (e.g., transmissible spongiform encephalopathies and Alzheimer disease). The development of rational strategies to interfere with aggregation is a potential therapeutic approach that r
Dipicolinic acid was extracted from approximately 0.1 mg spores or 0.5 ml of sporulating culture with 20 mM HCl for 10 min at 100 degrees C. The suspension was diluted with 5 mM Ca2+, 100 mM Tris, pH 7.6, centrifuged, and the first derivative of the uv absorbance spectrum recorded from 275 nm to 285