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Determination of pyrazoloimidazole in plasma and urine by gas—liquid chromatography using nitrogen—phosphorus detection

✍ Scribed by Matthew M. Ames; Garth Powis; Paul Kuehn


Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
273 KB
Volume
169
Category
Article
ISSN
1873-3778

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## Abstract A simple, specific and sensitive HPLC method has been developed for the determination of metoprolol in human plasma and urine. Separation of metoprolol and atenolol (internal standard) was achieved on an Ace C~18~ column (5 μm, 250 mm×4.6 mm id) using fluorescence detection with λ~ex~=2