Determination of pKa values using 15N an
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Jonathan W. Paschal; Douglas E. Dorman
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Article
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1978
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John Wiley and Sons
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English
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## Abstract By comparison of p__K__^a^ values derived from ^15^N and ^13^C nuclear magnetic resonance (NMR) spectroscopies, the assignment of the ^15^N resonances of apramycin is completed. ^13^C NMR spectra appear to provide accurate p__K__~a~ determinations with this aminoglycoside. Hydroxylation