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Determination of pKa values using 15N and 13C nuclear magnetic resonance spectroscopy. The case of apramycin

✍ Scribed by Jonathan W. Paschal; Douglas E. Dorman

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
195 KB
Volume
11
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

By comparison of p__K__^a^ values derived from ^15^N and ^13^C nuclear magnetic resonance (NMR) spectroscopies, the assignment of the ^15^N resonances of apramycin is completed. ^13^C NMR spectra appear to provide accurate p__K__~a~ determinations with this aminoglycoside. Hydroxylation adjacent to one of the basic nitrogens of apramycin appears to change the p__K__~a~ values of all five amines of the molecule.

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