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Determination of no-observed-adverse-effect levels and eliciting doses in a representative group of peanut-sensitized children

✍ Scribed by Flinterman, Annebeth E.; Pasmans, Suzanne G.; Hoekstra, Maarten O.; Meijer, Yolanda; van Hoffen, Els; Knol, Edward F.; Hefle, Susan L.; Bruijnzeel-Koomen, Carla A.; Knulst, André C.


Book ID
119276453
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
145 KB
Volume
117
Category
Article
ISSN
1097-6825

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Statistical issues on the determination
✍ Takashi Yanagawa; Yasuki Kikuchi 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 182 KB

## Abstract The determination of a safe exposure level for toxic agents, often defined as the highest dose level with no toxic effect and termed the no‐observed‐adverse‐effect level (NOAEL) is reviewed. The conventional methods based on statistical tests are criticized, particularly when the sample