A specific and quantitative assay for determining nanogram levels of nitroglycerin in plasma was developed. The method involves stabilization of the drug in plasma with silver nitrate, followed by multiple extraction using purified hexane. Isosorbide dinitrate is added as the internal standard. The
Determination of nitroglycerin in concentrated triturations
โ Scribed by Hutchison, George F.
- Publisher
- Elsevier
- Year
- 1940
- Weight
- 391 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0095-9553
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The plasma nitroglycerin levels obtained after intracardial (0.7 mg/kg), oral (7 mg/kg), and topical (7--14 mg/kg) doses of nitroglycerin in rats are reported. Nitroglycerin followed essentially one-compartment kinetics after intracardial administration, showing a mean half-life of about 4 min and a