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Rapid determination of nitroglycerin volatility using thermogravimetric analysis

✍ Scribed by H. Gucluyildiz; F. W. Goodhart; F. C. Ninger

Publisher: John Wiley and Sons
Year: 1977
Tongue: English
Weight: 243 KB
Volume: 66
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600660232

No coin nor oath required. For personal study only.

✦ Synopsis

The effect of selected tablet components on the volatility of nitroglycerin from compressed sublingual tablets was studied by thermogravimetric analysis. The results, confirmed by chemical analyses, showed that nitroglycerin volatility is significantly reduced by the use of povidone USP and microcrystalline cellulose NF in tablet formulations. In general, the stabilizing effect of these materials was dependent on the presence and the concentration of each other. These studies demonstrated the utility of thermogravimetric analysis as a rapid and reliable means of screening nitroglycerin formulations for stability purposes.

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