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Determination of N-5-dimethyl-9-[(2-methoxy-4-methylsulfonylamino)phenylamino]-4-acridinecarboxamide in plasma by high-performance liquid chromatography

✍ Scribed by Jeffrey L. Jurlina; James W. Paxton

Book ID
108449848
Publisher
Elsevier Science
Year
1985
Weight
283 KB
Volume
342
Category
Article
ISSN
0378-4347

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πŸ“œ SIMILAR VOLUMES

The clinical pharmacokinetics of N-5-dim
The clinical pharmacokinetics of N-5-dimethyl-9-[(2-methoxy-4-methyl-sulfonylamino)phenylamino]-4-acridinecarboxamide (CI-921) in a phase 1 trial
✍ J. W. Paxton; J. R. Hardy; P. C. Evans; V. J. Harvey; B. C. Baguley πŸ“‚ Article πŸ“… 1988 πŸ› Springer 🌐 English βš– 528 KB

The pharmacokinetics of CI-921 were studied after 65 infusions over a 20-fold dose range (13-270 mg/m2 per day) in 16 patients during a phase 1 trial. CI-921 was given by a 15 min infusion on three consecutive days. Plasma samples were collected after the first and third infusions, and urine, at 6 h