Phenothiazines are used as antipsychotic drugs and as reagents to determine microamounts of hemoglobin in biological fluids and tissues. Several agents cause the oxidation of phenothiazines to chromophoric cation radicals, whose stability may be related with their biological action. Enzymes and prot
Determination of molar absorptivities of radicals of 18 phenothiazine derivatives
โ Scribed by K. Minakata; O. Suzuki; Y. Ishikawa; H. Seno; N. Harada
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 728 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0379-0738
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Phenothiazines are of interest as model heterocyclic compounds and also as pharmacological agents with a wide spectrum of biological activities. Cation radicals derived from six phenothiazine derivatives including phenothiazine, 2-chlorophenothiazine, promazine, chlorpromazine, promethazine and trim
The hole transfer through DNA was monitored by the transient absorption of radical cation of phenothiazine (Ptz + ). The occurrence of hole transfer from G + generated in DNA to Ptz was observed in the time range of 100 ms. The hole transfer to Ptz was significantly suppressed by introducing oxG as