Hole transfer through DNA monitored by transient absorption of phenothiazine radical cation

✍ Scribed by Kiyohiko Kawai; Tadao Takada; Sachiko Tojo; Tetsuro Majima

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 119 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)02064-0

✦ Synopsis

The hole transfer through DNA was monitored by the transient absorption of radical cation of phenothiazine (Ptz + ). The occurrence of hole transfer from G + generated in DNA to Ptz was observed in the time range of 100 ms. The hole transfer to Ptz was significantly suppressed by introducing oxG as a hole trap in DNA, and the trapping reaction of oxG + by water was suggested to occur with the rate faster than 10 5 s -1 .