Determination of mitoxantrone using phase-selective a.c. adsorptive stripping voltammetry in a flow system with selectivity enhancement

✍ Scribed by Juan Carlos Cortina Villar; Agustin Costa García; Paulino Tuñon Blanco

• Publisher: Elsevier Science
• Year: 1992
• Tongue: English
• Weight: 538 KB
• Volume: 256
• Category: Article
• ISSN: 0003-2670
• DOI: 10.1016/0003-2670(92)85348-a

✦ Synopsis

A flow cell mcorporatmg a stationary carbon paste electrode coupled with a c voltammetry was used Preconcentratlon and determmatlon of the cancer chemotherapy drug mltoxantrone (MXT) were achieved via a flow-mjectlon approach utlhzmg adsorptton of the drug on the electrode, followed by medmm exchange and a c voltammetry on the adsorbed surface A hnear response was obtamed m the concentration range 5 x 10m9-1 5 x 10W7 M with aqueous samples The method was used for the determmatton of MXT m urme wlthout any sample pretreatment, the relatwe standard devlatlon obtamed was 1 1% (n = 5) with a concentration of 1 X 10m6 M The proposed method IS more selectwe than other methods suggested for the determmatlon of MXT m unne and plasma samples, which usually reqmre some kmd of sample pretreatment