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Determination of metabolites of benzene, toluene, ethylbenzene, and xylene by β-cyclodextrin modified capillary electrophoresis

✍ Scribed by Chin-Yu Wang; Ching-Te Huang; You-Zung Hsieh

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
154 KB
Volume
26
Category
Article
ISSN
1615-9306

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✦ Synopsis

Abstract

A β‐cyclodextrin modified capillary electrophoresis method for determining the metabolites of benzene, toluene, ethyl benzene, and xylene (BTEX) is described. Creatinine and uric acid were also examined as reference compounds. By employing a 20 mM, pH 10.0 borax‐NaOH buffer containing 7‐mM of β‐CD, ten analytes could be successfully separated within 10 min on a 50 μm capillary at an electric potential of 25 kV. The effects of pH and the concentration of β‐CD on the separation of the ten analytes are discussed. Under optimized separation conditions, the relative standard deviations for the migration times of the analytes were less than 0.93% and the correlation coefficients of the analyte linear calibration graphs exceeded 0.998 in the range from 1 to 300 μg/mL. Analyses of BTEX metabolites in urine samples from both occupationally exposed and non‐exposed subjects are shown herein. BTEX metabolites were determined in the urine sample of a gas station attendant.

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