✍ Scribed by P. Stenberg; T.-E. Jönsson; B. Nilsson; F. Wollheim
No coin nor oath required. For personal study only.
acid)' is one of several recently introduced anti-infIammatory agents based on a phenylpropionic acid structure. Previously described methods for the analysis of ketoprofen are based on colorim-et&, polarography', high-performance liquid chromatography (HPLC)3v", gasliquid chromatography (GLC)2v3,5 and thin-layer chromatography combined with GLC6 or with UV spectrophotometry'.
Except for the recently described HPLC methodj, these techniques are complicated or lack sensitivity_
In 1971, Ehrsson* introduced extractive alkylation for the derivatization of acidic compounds prior to quantification by GLC. Thanks to its simplicity, this technique has been applied to bioanalysis of a great number of drugs9-". In the present study, this derivatization procedure, combined with GLC 4th electroncapture detection, has been utilized for the determination of ketoprofen in plasma.
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A rapid, sensitive, and reliable method for the determination of nifedipine in human plasma is described. Using a single-step solvent extraction and capillary gas chromatography combined with electron capturedetection, an assaysensitivityof 2 ng/ml is achieved routinely using 0.5 ml of plasma. Intac