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Determination of isradipine and its pyridine metabolite in serum by capillary column gas chromatography with nitrogen-selective detection

โœ Scribed by Hanne Rolighed Christensen; Helle Riis Angelo; Kristjar Skajaa

Book ID
107996918
Publisher
Elsevier Science
Year
1992
Weight
364 KB
Volume
574
Category
Article
ISSN
0378-4347

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Enantioselective determination of isradi
Enantioselective determination of isradipine in human serum using chiral stationary phase liquid chromatography and gas chromatography with nitrogen selective detection
โœ Heidi S. Rask; Helle R. Angelo; Hanne R. Christensen ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 154 KB ๐Ÿ‘ 2 views

rac-Isradipine is a dihydropyridine type calcium antagonist. Its calcium entry blocking effect is due primarily to the (+)-(S)-enantiomer. This study describes a sensitive enantioselective method for the determination of isradipine in human serum. Following alkaline extraction into hexane, the enant