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Determination of isoniazid in pharmaceutical preparations by reaction with radiochloramine-B

โœ Scribed by M. Subhashini; M.S. Subramanian; V.R.S. Rao

Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
339 KB
Volume
7
Category
Article
ISSN
0731-7085

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โœฆ Synopsis

A method has been developed for the determination of isoniazid (INH) at microgram level in pharmaceutical preparations based on the oxidation of isoniazid by radiochloramine-B. Interference of vitamin C has been overcome by precipitation as lead ascorbate and that of rifampicin and p-aminosalicylic acid by selective extraction. Amounts as low as 25 micrograms of INH can be determined.

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