Determination of isoniazid and metabolites in biological fluids

✍ Scribed by Harold G. Boxenbaum; Sidney Riegelman

• Publisher: John Wiley and Sons
• Year: 1974
• Tongue: English
• Weight: 837 KB
• Volume: 63
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600630804

✦ Synopsis

Methods were developed for the determination of isoniazid and some of its metabolites in biological fluids. Isoniazid is determined in whole blood by a fluorometric procedure, and isoniazid and hydrazones, acetylisoniazid, isonicotinic acid, and isonicotinuric acid are determined in urine by colorimetry; each method is specific and accurate. Data are presented on these compounds following intravenous doses of isoniazid to both rapid and slow inactivator subjects of isoniazid.

Keyphrases Isoniazid and metabolites-fluorometric and colorimetric procedures for determination in biological samples 0 An- tituberculosis drugs-determination of isoniazid and metabolites in biological fluids Fluorometry-determination, isoniazid and metabolites in biological fluids Colorimetry-determination, isoniazid and metabolites in biological fluids ' Bausch and Lomb Spectronic 20.

8 Corning model 10.