Determination of Isomeric Nitriles with High-Performance Liquid Chromatography after Separation by Derivatization

✍ Scribed by George A. Pearse Jr.; Brad A. Bovenzi

• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 29 KB
• Volume: 57
• Category: Article
• ISSN: 0026-265X
• DOI: 10.1006/mchj.1996.1473

✦ Synopsis

A method is proposed for the separation of nitriles from other functional groups by derivatization. The resulting O-carboxamide amidoxime derivative of the nitrile is then identified by the use of HPLC retention times. The method has been successfully applied to isomeric monocyanopyridine and cyanotoluenes at a 1 mg/ml limit of detection.