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Determination of in Vitro- and in Vivo-Formed DNA Adducts of 2-Amino-3-methylimidazo[4,5- f ]quinoline by Capillary Liquid Chromatography/Microelectrospray Mass Spectrometry

✍ Scribed by Gangl, Eric T.; Turesky, Robert J.; Vouros, Paul

Book ID
125945179
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
263 KB
Volume
12
Category
Article
ISSN
0893-228X

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## Abstract In studying the metabolic pathways underlying the mechanism of carcinogenesis of the heterocyclic amine of 2‐amino‐3‐methylimidazo[4,5‐__f__]quinoline (IQ), we recently found a new metabolite which gave an [M + H]^+^ ion of __m__/__z__ 217 when subjected to electrospray ionization (ESI)

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## Abstract 2‐Amino‐3‐methylimidazo[4,5‐__f__]quinoline (IQ) and 2‐amino‐3,8‐dimethylimidazo[4,5‐__f__]quinoxaline (MelQx) are carcinogens found in cooked meats that form DNA adducts upon metabolic activation. Purified DNA from Chinese hamster ovary (CHO) cells was reacted in vitro with the active