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Determination of imipenem (N-formimidoyl thienamycin) in human plasma and urine by high-performance liquid chromatography, comparison with microbiological methodology and stability

โœ Scribed by D.A. Gravallese; D.G. Musson; L.T. Pauliukonis; W.F. Bayne

Book ID
107996448
Publisher
Elsevier Science
Year
1984
Weight
927 KB
Volume
310
Category
Article
ISSN
0378-4347

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Determination of imipenem in human plasm
Determination of imipenem in human plasma, urine and tissue by high-performance liquid chromatography
โœ G. Carlucci; L. Biordi; C. Vicentini; M. Bologna ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 346 KB

A simple and reliable HPLC method is described for the new beta-lactam antibiotic imipenem; suitable extraction procedures for the drug in human plasma, urine and prostatic tissue are described. The figures of merit for the assays are reported and examples given of their application.