Determination of fluidized bed granulation end point using near-infrared spectroscopy and phenomenological analysis

✍ Scribed by W. Paul Findlay; Garnet R. Peck; Kenneth R. Morris

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 167 KB
• Volume: 94
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.20276

✦ Synopsis

Simultaneous real-time monitoring of particle size and moisture content by near-infrared spectroscopy through a window into the bed of a fluidized bed granulator is used to determine the granulation end point. The moisture content and particle size determined by the near-infrared monitor correlates well with off-line moisture content and particle size measurements. The measured particle size is modeled using a population balance approach, and the moisture content is shown to follow accepted models during drying. Given a known formulation, with predefined parameters for peak moisture content, final moisture content, and final granule size, the near-infrared monitoring system can be used to control a fluidized bed granulation by determining when binder addition should be stopped and when drying of the granules is complete.