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Determination of epoxide hydrolase activity by high performance liquid chromatography

โœ Scribed by L. V. Kravchenko; V. S. Sobolev

Publisher
Springer US
Year
1989
Tongue
English
Weight
228 KB
Volume
108
Category
Article
ISSN
0007-4888

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Rapid Determination of Soluble Epoxide Hydrolase Inhibitors in Rat Hepatic Microsomes by High-Performance Liquid Chromatography with Electrospray Tandem Mass Spectrometry
โœ Takaho Watanabe; Bruce D. Hammock ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 109 KB

A rapid and reliable electrospray tandem mass spectrometric method for soluble epoxide hydrolase (sEH) inhibitors in rat hepatic microsomes is described. Four synthesized sEH inhibitors were extracted from rat hepatic microsomes with ethyl acetate and were determined by HPLC using positive ion elect