Determination of enantiomeric composition of 2-phenyl-2-(2-piperidyl)acetamide. A routine method for evaluation of enantiomeric purity of primary amides
β Scribed by Branko S. Jursic; Zoran Zdravkovski; Miljenko Zuanic
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 353 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0957-4166
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β¦ Synopsis
Several NMR chiral resolving agents have successfully been used to demonstrate
π SIMILAR VOLUMES
## Abstract (__S__)β2βChloropropanoyl chloride reacts cleanly with Ξ±βsubstituted Ξ±βhydroxy acids (or esters) to give __O__βacyl derivatives, which can be used for the establishment of optical purities of the acids or their esters.
The N-(n-butylamide) of (S)-2-(phenylcarbamoyloxy)propionic acid, easily prepared starting from the inexpensive L-ethyl lactate, can be used as convenient chiral solvating agent (CSA) to determine the enantiomeric composition of N-(3,5-dinitrobenzoyl)amino acid methyl esters.